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As far asDC‘s are concerned it was found that either inhibiting STAT3 in human DCs or removing theSTAT3 gene in transgenic mice results in an increased DC function compared to control DC.In mice that were transgenic for the deletion of the STAT3 gene, DC‘s demonstrated highercytokine secretion in response to TLR stimulation, could activated T cells more efficiently,and were resistant to tumor induced inhibition of cytokine production when compared tonormal mouse DC

As far asDC‘s are concerned it was found that either inhibiting STAT3 in human DCs or removing theSTAT3 gene in transgenic mice results in an increased DC function compared to control DC.In mice that were transgenic for the deletion of the STAT3 gene, DC‘s demonstrated highercytokine secretion in response to TLR stimulation, could activated T cells more efficiently,and were resistant to tumor induced inhibition of cytokine production when compared tonormal mouse DC. The mTOR is an important link inthe cascade of signalling pathways which leadto proliferation and differentiation of T-cellsactivated by IL-2 and other cytokines

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These were initially red, which became bluish and black after few days. In uni-cellular exocrine glands, the secretory component consistsof single cells distributed among other nonsecretory cells.A typical example is the goblet cell, a mucus-secreting cellpositioned among other columnar cells (Fig.

Afterenrollment of 3 236 patients, the trial was stopped due to safetyconcerns, as the primary outcome occurred in 43 patients in thedronedarone arm when compared to 19 in the placebo arm(HR 2.29; 95% CI 1.34–3.94; p = 0.002).

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